In pentobarbital anaesthetized rats, ATP sensitive potassium channel activator pinacidil and calcium channel antagonist nifedipine at the dose of 1.0 mg/ kg ( iv) decreased blood pressure and heart rate, and depressed cardiac functions. 在戊巴比妥钠麻醉的大鼠上,ATP敏感性钾通道激活剂吡那地尔及钙通道拮抗剂硝苯地平均可降低血压,减慢心率,抑制心脏收缩与舒张功能。